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Embryo Mortality in Isg15−/− Mice Is Exacerbated by Environmental Stress1

11 Dec 2014

Abstract excerpt

The interferon-stimulated gene 15 (Isg15) encodes a ubiquitin-like protein that is induced in the endometrium by pregnancy in mice, humans, and ruminants. Because ISG15 is a component of the innate immune system, we hypothesized that development of the embryo, fetus, and postnatal pup may be impaired in mice lacking Isg15 (Isg15(-/-)) and that this development would be further impaired in response to...

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PMID: 25505199
DOI: 10.1095/biolreprod.114.122002

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Click a neighbor to travelStep 1 · 12 closest

Embryo Mortality in Isg15−/− Mice Is Exacerbated by Environmental Stress1PMID 25505199Read ↗

Interferon-Stimulated Gene-15 (<i>Isg15</i>) Expression Is Up-Regulated in the Mouse Uterus in Response to the Implanting ConceptusSemantic proximity Read ↗

Interferon Stimulated Gene 15 Conjugates to Endometrial Cytosolic Proteins and Is Expressed at the Uterine-Placental Interface throughout Pregnancy in SheepSemantic proximity Read ↗

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ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1Semantic proximity Read ↗

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Natural killer-cell deficiency alters placental development in rats†Semantic proximity Read ↗

Preeclampsia is Associated With Reduced ISG15 Levels Impairing Extravillous Trophoblast InvasionSemantic proximity Read ↗

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IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesSemantic proximity Read ↗

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