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Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging

30 Mar 2022

Abstract excerpt

Abstract: The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane and is implicated in several functions, including cholesterol transport and stereoidogenesis. Under normal physiological conditions, TSPO is present in very low concentrations in the human brain but is markedly upregulated in response to brain injury and inflammation. This upregulation is strongly associated with...

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PMID: 35352645
DOI: 10.2174/0929867329666220329204054

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