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Article

Mesothelioma developing in carriers of inherited genetic mutations

1 Feb 2020

Abstract excerpt

Abstract: Malignant mesothelioma is associated with the exposure to asbestos fibers. Recent discovery of the BAP1 cancer syndrome, a Mendelian disorder with high-penetrance autosomal dominant inheritance fostered the genotyping for nucleotide-level or larger structural alteration of germline DNA. Inherited heterozygous mutations of the BAP1 gene increase the susceptibility to carcinogenic fibers, leading to a...

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PMID: 32206572
DOI: 10.21037/tlcr.2019.11.15

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