Article
Beyond environmental risk: Genetic insights into lung cancer susceptibility through whole exome analysis.
Lung cancer (Amsterdam, Netherlands) - 1 Jun 2025
Lintas C, Petti R, Colella G, Cassano I, Azzarà A, Cortellini A, Longo F, Frasca L, Gurrieri F, Crucitti P
Abstract excerpt
BACKGROUND: unlike familial non polyposis colorectal cancer (Lynch syndrome) and familial breast cancer, no genes have been confidently associated with familial lung cancer with the exception of the EGFR and the TP53 genes. Germinal Pathogenetic Variants (GPV) in these two genes account for 0.34-0.9% and 0.8 % lung adenocarcinoma, respectively. OBJECTIVE: the aim of this study was to identify rare genetic...
Read the complete abstract on PubMedTopics
- Humans
- Lung Neoplasms
- Genetic Predisposition to Disease
- Female
- Male
- Exome Sequencing