Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Malignant pleural mesothelioma: Germline variants in DNA repair genes may steer tailored treatment

12 Jan 2022

Abstract excerpt

INTRODUCTION: Malignant pleural mesothelioma (MPM) is a tumour associated with asbestos exposure. Approximately, 10% of patients with MPM carry a germline pathogenic variant (PV), mostly in DNA repair genes, suggesting the occurrence of inherited predispositions. AIM: This article aimed to 1) search for new predisposing genes and assess the prevalence of PVs in DNA repair genes, by next-generation sequencing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to Occupational and environmental lung diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35032816
DOI: 10.1016/j.ejca.2021.12.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Malignant pleural mesothelioma: Germline variants in DNA repair genes may steer tailored treatmentPMID 35032816Read ↗

Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas.Semantic proximity Read ↗

New pathogenic germline variants identified in mesothelioma.Semantic proximity Read ↗

Germline mutations in DNA repair genes predispose asbestos-exposed patients to malignant pleural mesothelioma.Semantic proximity Read ↗

Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.Semantic proximity Read ↗

Inherited predisposition to malignant mesothelioma: germline BAP1 mutations and beyond.Semantic proximity Read ↗

Family Matters: Germline Testing in Thoracic Cancers.Semantic proximity Read ↗

Novel LRRK2 mutations and other rare, non-BAP1-related candidate tumor predisposition gene variants in high-risk cancer families with mesothelioma and other tumors.Semantic proximity Read ↗

Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review.Semantic proximity Read ↗

Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.Semantic proximity Read ↗

Genomic Landscape of Malignant Mesotheliomas.Semantic proximity Read ↗

Comprehensive genomic and transcriptomic analysis enables molecularly guided therapy options in peritoneal and pleural mesotheliomaSemantic proximity Read ↗

Molecular alterations and potential actionable mutations in peritoneal mesothelioma: a scoping review of high-throughput sequencing studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.