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Article

Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians.

Thyroid : official journal of the American Thyroid Association - 1 Jan 2012

Nair Saraswathy, Muller Yunhua Li, Ortega Emilio, Kobes Sayuko, Bogardus Clifton, Baier Leslie J

Abstract excerpt

BACKGROUND: The type 2 deiodinase gene (DIO2) encodes a deiodinase that converts the thyroid prohormone, thyroxine, to the biologically active triiodothyronine. Thyroid hormones regulate energy balance and may also influence glucose metabolism. Therefore, we hypothesized that variations in DIO2 could contribute to obesity or type 2 diabetes mellitus (T2DM) in Pima Indians. METHODS: Sequencing of the DIO2 gene in...

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Source

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Identifiers

PMID: 22142372
DOI: 10.1089/thy.2010.0455
PMCID: PMC3247704

Genes

DIO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians.PMID 22142372Read ↗

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects.Semantic proximity Read ↗

The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance.Semantic proximity Read ↗

Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.Semantic proximity Read ↗

Association Between a Novel Variant of the Human Type 2 Deiodinase Gene Thr92Ala and Insulin ResistanceSemantic proximity Read ↗

The Physiological Functions and Polymorphisms of Type II DeiodinaseSemantic proximity Read ↗

The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish.Semantic proximity Read ↗

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Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis.Semantic proximity Read ↗

PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.Semantic proximity Read ↗

Exome Sequencing Identifies A Nonsense Variant in DAO Associated With Reduced Energy Expenditure in American Indians.Semantic proximity Read ↗

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