Article
Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program.
Translational psychiatry - 5 May 2023
Cheng Youshu, Dao Cecilia, Zhou Hang, Li Boyang, Kember Rachel L, Toikumo Sylvanus, Zhao Hongyu, Gelernter Joel, Kranzler Henry R, Justice Amy C, Xu Ke
Abstract excerpt
Smoking behaviors and alcohol use disorder (AUD), both moderately heritable traits, commonly co-occur in the general population. Single-trait genome-wide association studies (GWAS) have identified multiple loci for smoking and AUD. However, GWASs that have aimed to identify loci contributing to co-occurring smoking and AUD have used small samples and thus have not been highly informative. Applying multi-trait...
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