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Article

Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.

The American journal of psychiatry - 1 Aug 2023

Kember Rachel L, Vickers-Smith Rachel, Zhou Hang, Xu Heng, Jennings Mariela, Dao Cecilia, Davis Lea, Sanchez-Roige Sandra, Justice Amy C, Gelernter Joel, Vujkovic Marijana, Kranzler Henry R

Abstract excerpt

OBJECTIVE: Recent genome-wide association studies (GWASs) of alcohol-related phenotypes have uncovered key differences in the underlying genetic architectures of alcohol consumption and alcohol use disorder (AUD), with the two traits having opposite genetic correlations with psychiatric disorders. Understanding the genetic factors that underlie the transition from heavy drinking to AUD has important theoretical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37282553
DOI: 10.1176/appi.ajp.21090892
PMCID: PMC10731616

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