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Article

Therapy-induced malignant neoplasms in Nf1 mutant mice.

Cancer cell - 1 Oct 2005

Chao Richard C, Pyzel Urszula, Fridlyand Jane, Kuo Yien-Ming, Teel Lewis, Haaga Jennifer, Borowsky Alexander, Horvai Andrew, Kogan Scott C, Bonifas Jeannette, Huey Bing, Jacks Tyler E, Albertson Donna G, Shannon Kevin M

Abstract excerpt

Therapy-induced cancers are a severe complication of genotoxic therapies. We used heterozygous Nf1 mutant mice as a sensitized genetic background to investigate tumor induction by radiation (RAD) and cyclophosphamide (CY). Mutagen-exposed Nf1(+/-) mice developed secondary cancers that are common in humans, including myeloid malignancies, sarcomas, and breast cancers. RAD cooperated strongly with heterozygous Nf1...

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Identifiers

PMID: 16226708
DOI: 10.1016/j.ccr.2005.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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