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Article

Kras mutations and PU.1 promoter methylation are new pathways in murine radiation-induced AML.

Carcinogenesis - 12 Aug 2020

O'Brien Gráinne, Cruz-Garcia Lourdes, Zyla Joanna, Brown Natalie, Finnon Rosemary, Polanska Joanna, Badie Christophe

Abstract excerpt

Therapy-related and more specifically radiotherapy-associated acute myeloid leukaemia (AML) is a well-recognized potential complication of cytotoxic therapy for the treatment of a primary cancer. The CBA mouse model is used to study radiation leukaemogenesis mechanisms with Sfpi1/PU.1 deletion and point mutation already identified as driving events during AML development. To identify new pathways, we analysed 123...

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Identifiers

PMID: 31646336
DOI: 10.1093/carcin/bgz175
PMCID: PMC7422620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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