Article
Genomic alterations of cerebrospinal fluid cell-free DNA in leptomeningeal metastases of gastric cancer.
Journal of translational medicine - 2 May 2023
Chen Xin, Bai Kaixuan, Zhang Yu, Xu Yang, Huo Yinghao, Wang Sha, Zou Yueli, Qi Xuejiao, Guo Rongyun, Ou Qiuxiang, Liu Dengxiang, Yin Shaohua, Chen Shubo, Bu Hui
Abstract excerpt
BACKGROUND: Leptomeningeal metastases (LM) were rare in gastric cancer (GC), and GC patients with LM (GCLM) generally suffer from poor prognosis. Nevertheless, the clinical utility of cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) was underinvestigated in GCLM. METHODS: We retrospectively studied 15 GCLM patients, and all patients had paired primary tumor tissue samples and post-LM CSF samples while 5...
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