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Article

Evaluating the cerebrospinal fluid ctDNA detection by next-generation sequencing in the diagnosis of meningeal Carcinomatosis.

BMC neurology - 19 Dec 2019

Zhao Yue, He Jun-Ying, Zou Yue-Li, Guo Xiao-Su, Cui Jun-Zhao, Guo Li, Bu Hui

Abstract excerpt

BACKGROUND: Meningeal carcinomatosis (MC) is the most severe form of brain metastasis and causes significant morbidity and mortality. Currently, the diagnosis of MC is routinely confirmed on the basis of clinical manifestation, positive cerebrospinal fluid (CSF) cytology, and/or neuroimaging features. However, negative rate of CSF cytology and neuroimaging findings often result in a failure to diagnose MC from...

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Identifiers

PMID: 31856745
DOI: 10.1186/s12883-019-1554-5
PMCID: PMC6924020

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