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Article

Plasmodium falciparum kelch13 polymorphisms identified after treatment failure with artemisinin-based combination therapy in Niger.

Malaria journal - 1 May 2023

Arzika Ibrahima Issa, Lobo Neil F, Lamine Mahaman Moustapha, Tidjani Ilagouma Amadou, Sandrine Houzé, Sarrasin-Hubert Véronique, Mahamadou Aboubacar, Adehossi Eric, Sarr Demba, Mahmud Ousman, Maman Laminou Ibrahim

Abstract excerpt

BACKGROUND: Artemisinin-based combination therapy (ACT) is the most effective treatment for malaria, and has significantly reduced morbimortality. Polymorphisms associated with the Plasmodium falciparum Kelch gene (Pfkelch13) have been associated with delayed parasite clearance even with ACT treatment. METHODS: The Pfkelch13 gene was sequenced from P. falciparum infected patients (n = 159) with uncomplicated...

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Identifiers

PMID: 37127669
DOI: 10.1186/s12936-023-04571-w
PMCID: PMC10150466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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