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Article

Polymorphisms in Pfkelch13 domains before and after the introduction of artemisinin-based combination therapy in Southwest Nigeria.

PloS one - 1 Jan 2025

Amusan Abiodun, Akinola Olugbenga, Akano Kazeem, Hernández-Castañeda María, Dick Jenna K, Sowunmi Akintunde, Hart Geoffrey, Gbotosho Grace

Abstract excerpt

Emergence of artemisinin resistance in East Africa has greatly necessitated surveillance of artemisinin resistance in other African countries with great malaria burden. Specific mutations within the β-propeller and BTB/Poz domains of Pfkelch13 gene are validated markers of artemisinin resistance. Sparse information exists on mutations outside these domains that may also contribute to artemisinin resistance. This...

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Identifiers

PMID: 40163420
DOI: 10.1371/journal.pone.0316479
PMCID: PMC11957316

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