Back to search

Article

CRISPR targeting of SNPs associated with Age-related Macular Degeneration in ARPE-19 cells: a potential model for manipulating the complement system

2024-08-13

Abstract excerpt

<title>Abstract</title> <p>Age-related Macular degeneration (AMD) is a major cause of vision loss, linked to several predisposing single nucleotide polymorphisms (SNPs). CRISPR-mediated genome editing offers the potential to target negatively associated SNPs in an allele-specific manner, necessitating the use of a relevant cell model. The ARPE-19 cell line, with its stable monolayer growth and retinal pigment epi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f722325e-1cf1-5617-ba29-ce14de3bd85a
DOI
10.21203/rs.3.rs-4755651/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
CRISPR targeting of SNPs associated with Age-related Macular Degeneration in ARPE-19 cells: a potential model for manipulating the complement systemDOI 10.21203/rs.3.rs-4755651/v1
CRISPR targeting of SNPs associated with age-related macular degeneration in ARPE-19 cells: a potential model for manipulating the complement system.Semantic proximity
CRISPR Manipulation of Age-Related Macular Degeneration Haplotypes in the Complement System: Potential Future Therapeutic Applications/Avenues.Semantic proximity
CRISPR editing demonstrates rs10490924 raised oxidative stress in iPSC-derived retinal cells from patients with ARMS2/HTRA1-related AMD.Semantic proximity
Engineering single-AAV CRISPR-Cas13 RNA base editors for treatment of inherited retinal diseasesSemantic proximity
Functional study of the AMD-associated gene <i>TMEM97</i> in retinal pigmented epithelium using CRISPR interferenceSemantic proximity
Genome-Editing Strategies for Treating Human Retinal DegenerationsSemantic proximity
From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseasesSemantic proximity
CRISPR-Cas9 Gene Therapy Effects on Inherited Eye DisordersSemantic proximity
CRISPR Interference-Potential Application in Retinal Disease.Semantic proximity
CRISPR-Based Genome Editing as a New Therapeutic Tool in Retinal Diseases.Semantic proximity
Therapeutic applications of CRISPR /Cas9 gene editing technology for the treatment of ocular diseasesSemantic proximity
Base and Prime Editing in the Retina—From Preclinical Research toward Human Clinical TrialsSemantic proximity
Select a neighboring publication to make it the new centre.