Article
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan.
Nature aging - 1 May 2022
Ribeiro Rui, Macedo Joana C, Costa Madalena, Ustiyan Vladimir, Shindyapina Anastasia V, Tyshkovskiy Alexander, Gomes Rita N, Castro José Pedro, Kalin Tanya V, Vasques-Nóvoa Francisco, Nascimento Diana S, Dmitriev Sergey E, Gladyshev Vadim N, Kalinichenko Vladimir V, Logarinho Elsa
Abstract excerpt
The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal non-transcriptional functions in various biological processes critical for cellular homeostasis. We previously found that FOXM1 repression during cellular aging underlies the senescence phenotypes, which were vastly restored by overexpressing transcriptionally active FOXM1. Yet, it remains unknown whether increased...
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