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Article

Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet.

Aging cell - 1 Feb 2019

Kreienkamp Ray, Billon Cyrielle, Bedia-Diaz Gonzalo, Albert Carolyn J, Toth Zacharie, Butler Andrew A, McBride-Gagyi Sara, Ford David A, Baldan Angel, Burris Thomas P, Gonzalo Susana

Abstract excerpt

Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients. Barriers to developing effective therapies include the unknown etiology of progeria mice early death, seemingly unrelated to the reported atherosclerosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30548460
DOI: 10.1111/acel.12852
PMCID: PMC6351834

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