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Regulation of the master regulator FOXM1 in cancer

12 Sept 2018

Abstract excerpt

FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis. In most human cancers, FOXM1 is overexpressed, and this indicates a poor prognosis for cancer patients. FOXM1 maintains cancer hallmarks by regulating the...

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PMID: 30208972
DOI: 10.1186/s12964-018-0266-6

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