Article

Chemical enhancement of DNA repair in aging

2025-02-27

Abstract excerpt

DNA damage is a central driver of the aging process. We previously found that KIF2C, known to play a role in DNA repair, is repressed in aged cells. Here, we investigated if increased KIF2C activity counteracts DNA damage and its effects on aging phenotypes. We show that a small-molecule agonist of KIF2C enhances DNA repair in two distinct genetic disorders exhibiting DNA damage and accelerated aging, the Hutchins...

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Literature Corpus work: dbd06fb0-1ef0-53f9-8864-93ffd154cf6e
DOI: 10.1101/2025.02.21.639496

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