Article

The senescence-inhibitory p53 isoform Δ133p53α represses the proinflammatory chemokine CXCL10 in progeria model mice and naturally aged mice

2026-04-02

Abstract excerpt

<h4>Aims</h4> Δ133p53α is a naturally occurring isoform of the human p53 protein that inhibits p53-mediated cellular senescence. We previously reported that transgenic expression of this senescence-inhibitory p53 isoform counteracts aging-associated pathological changes in progeria model mice (heterozygous Lmna G609G/+ ). The anti-aging effect of Δ133p53α was attributed in part to reduced levels of the proinfla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 55835813-f29d-5ab1-bd26-03049928eee6
DOI: 10.64898/2026.03.31.715385

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The senescence-inhibitory p53 isoform Δ133p53α represses the proinflammatory chemokine CXCL10 in progeria model mice and naturally aged miceDOI 10.64898/2026.03.31.715385Read

Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortalitySemantic proximity Read

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cellsSemantic proximity Read

p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological FunctionsSemantic proximity Read

Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoformSemantic proximity Read

Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescenceSemantic proximity Read

Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence.Semantic proximity Read

Does Δ133p53 isoform trigger inflammation and autoimmunity?Semantic proximity Read

Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment.Semantic proximity Read

Endothelial and systemic upregulation of miR-34a-5p fine-tunes senescence in progeriaSemantic proximity Read

Aging, longevity, inflammation, and cancer.Semantic proximity Read

In vivo stress reporters as early biomarkers of the cellular changes associated with progeria.Semantic proximity Read

Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long‐lived and cancer‐resistant subterranean wild rodent, SpalaxSemantic proximity Read