Article
Exome sequencing of three cases of familial exceptional longevity.
Aging cell - 1 Dec 2014
Cash Timothy P, Pita Guillermo, Domínguez Orlando, Alonso Maria R, Moreno Leticia T, Borrás Consuelo, Rodríguez-Mañas Leocadio, Santiago Catalina, Garatachea Nuria, Lucia Alejandro, Avellana Juan A, Viña Jose, González-Neira Anna, Serrano Manuel
Abstract excerpt
Exceptional longevity (EL) is a rare phenotype that can cluster in families, and co-segregation of genetic variation in these families may point to candidate genes that could contribute to extended lifespan. In this study, for the first time, we have sequenced a total of seven exomes from exceptionally long-lived siblings (probands ≥ 103 years and at least one sibling ≥ 97 years) that come from three separate...
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