Article

Discovering pathways through ribozyme fitness landscapes using information theoretic quantification of epistasis

2023-05-24

Abstract excerpt

The identification of catalytic RNAs is typically achieved through primarily experimental means. However, only a small fraction of sequence space can be analyzed even with high-throughput techniques. Methods to extrapolate from a limited data set to predict additional ribozyme sequences, particularly in a human-interpretable fashion, could be useful both for designing new functional RNAs and for generating greater...

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Literature Corpus work: cfa52cde-da11-5440-b932-22c0a29a0884
DOI: 10.1101/2023.05.22.541765

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