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Article

An orthogonal ribosome-tRNA pair via engineering of the peptidyl transferase center.

Nature chemical biology - 1 Jul 2014

Terasaka Naohiro, Hayashi Gosuke, Katoh Takayuki, Suga Hiroaki

Abstract excerpt

The Watson-Crick base pairs between the 3'-terminal end of tRNAs and ribosomal RNA in the peptidyl transferase center are universally conserved. Here, we report that the introduction of compensatory mutations to Escherichia coli RNAs in this site leads to an orthogonal system independent of the w...

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Source

Identifiers

PMID: 24907900
DOI: 10.1038/nchembio.1549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24907900-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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