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Article

Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2016

Liu Qi, Li Xiaoxia, Li Sen, Qu Shengqiang, Wang Yu, Tang Qingzhu, Ma Hongwei, Luo Yang

Abstract excerpt

Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by the development of hundreds to thousands of colonic adenomas and an increased risk of colorectal cancer. Adenomatous polyposis coli (APC), encoding a large multidomain protein involved in antagonizing the Wnt signaling pathway, has been identified as the main causative gene responsible for FAP. In this study, we identified...

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Source

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Identifiers

PMID: 27000756
DOI: 10.1007/s13277-016-4986-1
PMCID: PMC4999466

Genes

APC
FAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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