Article
Genes implicated by a methylome-wide schizophrenia study in neonatal blood show differential expression in adult brain samples.
Molecular psychiatry - 1 May 2023
van den Oord Edwin J C G, Xie Lin Y, Zhao Min, Campbell Thomas L, Turecki Gustavo, Kähler Anna K, Dean Brian, Mors Ole, Hultman Christina M, Staunstrup Nicklas H, Aberg Karolina A
Abstract excerpt
Schizophrenia is a disabling disorder involving genetic predisposition in combination with environmental influences that likely act via dynamic alterations of the epigenome and the transcriptome but its detailed pathophysiology is largely unknown. We performed cell-type specific methylome-wide association study of neonatal blood (N = 333) from individuals who later in life developed schizophrenia and controls....
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