Article
Compendium of aberrant DNA methylation and histone modifications in cancer.
Biochemical and biophysical research communications - 5 Dec 2014
Hattori Naoko, Ushijima Toshikazu
Abstract excerpt
Epigenetics now refers to the study or research field related to DNA methylation and histone modifications. Historically, global DNA hypomethylation was first revealed in 1983, and, after a decade, silencing of a tumor suppressor gene by regional DNA hypermethylation was reported. After the proposal of the histone code in the 2000s, alterations of histone methylation were also identified in cancers. Now, it is...
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