Article
Protein-Targeted Glycan Editing on Living Cells Disrupts KRAS Signaling.
Angewandte Chemie (International ed. in English) - 26 Jun 2023
Li Yiran, Huo Fan, Chen Liusheng, Wang Haiqi, Wu Jianzhuang, Zhang Peiwen, Feng Nan, Li Wei, Wang Lan, Wang Yichun, Wang Xiaojian, Yang Xiaoliang, Lu Zhiqiang, Mao Yang, Yan Chao, Ding Lin, Ju Huangxian
Abstract excerpt
The frequent mutation of KRAS oncogene in some of the most lethal human cancers has spurred incredible efforts to develop KRAS inhibitors, yet only one covalent inhibitor for the KRASG12C mutant has been approved to date. New venues to interfere with KRAS signaling are desperately needed. Here, we report a "localized oxidation-coupling" strategy to achieve protein-specific glycan editing on living cells for...
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