Article

Glycoengineering of extracellular vesicles enhances cellular uptake and cargo delivery to target cells

2026-03-23

Abstract excerpt

<h4>ABSTRACT</h4> The glycocalyx is a major regulator of membrane recognition, yet its specific influence on extracellular vesicles (EVs) cellular uptake remains poorly defined. We established a genetic glycoengineering platform to systematically investigate how the major glycan classes on small EVs (sEVs) modulate cell interactions and functional cargo delivery. Using an isogenic panel of HEK293F lines lacking d...

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Literature Corpus work: 9f7ba46e-117c-5656-95bc-239f19c06423
DOI: 10.64898/2026.03.20.713142

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