Article
Bi-level structured functional analysis for genome-wide association studies.
Biometrics - 1 Dec 2023
Wu Mengyun, Wang Fan, Ge Yeheng, Ma Shuangge, Li Yang
Abstract excerpt
Genome-wide association studies (GWAS) have led to great successes in identifying genotype-phenotype associations for complex human diseases. In such studies, the high dimensionality of single nucleotide polymorphisms (SNPs) often makes analysis difficult. Functional analysis, which interprets SNPs densely distributed in a chromosomal region as a continuous process rather than discrete observations, has emerged...
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