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Article

Hypoxia hits APOL1 in the kidney.

Kidney international - 1 Jul 2023

Grampp Steffen, Krüger René, Lauer Victoria, Uebel Sebastian, Knaup Karl X, Naas Julia, Höffken Verena, Weide Thomas, Schiffer Mario, Naas Stephanie, Schödel Johannes

Abstract excerpt

Individuals of African ancestry carrying two pathogenic variants of apolipoprotein 1 (APOL1) have a substantially increased risk for developing chronic kidney disease. The course of APOL1 nephropathy is extremely heterogeneous and shaped by systemic factors such as a response to interferon. However, additional environmental factors operating in this second-hit model have been less well defined. Here, we reveal...

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Identifiers

PMID: 37098381
DOI: 10.1016/j.kint.2023.03.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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