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Article

New ideas about mechanism in APOL1 kidney disease.

Kidney international - 1 Sept 2026

Friedman David J, Pollak Martin R

Abstract excerpt

Apolipoprotein L1 risk variants contribute to high rates of kidney disease among individuals of African ancestry. These gain-of-function variants cause toxicity to kidney cells, but the mechanism of injury is not clear. Many theories have been proposed, yet the field has not arrived at a consensus. Kim et al. make a compelling argument for a peroxisomal pathway of injury specifically activated under hypoxic...

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Source

Identifiers

PMID: 42624538
DOI: 10.1016/j.kint.2026.05.021

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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