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Article

Structural alterations within native amyloidogenic immunoglobulin light chains.

Journal of molecular biology - 29 May 2009

Randles Edward G, Thompson James R, Martin Douglas J, Ramirez-Alvarado Marina

Abstract excerpt

Amyloid diseases are characterized by the misfolding of a precursor protein that leads to amyloid fibril formation. Despite the fact that there are different precursors, some commonalities in the misfolding mechanism are thought to exist. In light chain amyloidosis (AL), the immunoglobulin light chain forms amyloid fibrils that deposit in the extracellular space of vital organs. AL proteins are thermodynamically...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19361523
DOI: 10.1016/j.jmb.2009.04.010
PMCID: PMC2840394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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