Loss of Stat3 in Osterix+ cells impairs dental hard tissues development

Abstract excerpt

BACKGROUND: Mutations in the signal transducers and activators of transcription 3 (STAT3) gene result in hyper-IgE syndrome(HIES), a rare immunodeficiency that causes abnormalities in immune system, bones and teeth. However, the role of Stat3 in development of dental hard tissues was yet to investigate. METHODS: , Stat3 CKO) was made. The differences of postnatal tooth development between control and Stat3 CKO...

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