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Article

Runx1-Stat3 signaling regulates the epithelial stem cells in continuously growing incisors.

Scientific reports - 19 Jul 2018

Sarper Safiye E, Inubushi Toshihiro, Kurosaka Hiroshi, Ono Minagi Hitomi, Kuremoto Koh-Ichi, Sakai Takayoshi, Taniuchi Ichiro, Yamashiro Takashi

Abstract excerpt

Rodent incisors grow permanently and the homeostasis of enamel production is maintained by a continuous supply of epithelial progenitors from putative stem cells in the cervical loop. We herein report that Runx1 regulates the Lgr5-expressing epithelial stem cells and their subsequent continuous differentiation into ameloblasts. Mice deficient in epithelial Runx1 demonstrate remarkable shortening of the incisors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 30026553
DOI: 10.1038/s41598-018-29317-6
PMCID: PMC6053438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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