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Article

Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb-/-Runx2+/- Murine Incisors.

Scientific reports - 26 Mar 2018

Saito Kazuyuki, Takahashi Katsu, Huang Boyen, Asahara Masakazu, Kiso Honoka, Togo Yumiko, Tsukamoto Hiroko, Mishima Sayaka, Nagata Masaki, Iida Machiko, Tokita Yoshihito, Asai Masato, Shimizu Akira, Komori Toshihisa, Harada Hidemitsu, MacDougall Mary, Sugai Manabu, Bessho Kazuhisa

Abstract excerpt

Adult Cebpb KO mice incisors present amelogenin-positive epithelium pearls, enamel and dentin allopathic hyperplasia, fewer Sox2-positive cells in labial cervical loop epitheliums, and reduced Sox2 expression in enamel epithelial stem cells. Thus, Cebpb acts upstream of Sox2 to regulate stemness. In this study, Cebpb KO mice demonstrated cementum-like hard tissue in dental pulp, loss of polarity by ameloblasts,...

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Identifiers

PMID: 29581460
DOI: 10.1038/s41598-018-23515-y
PMCID: PMC5980103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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