Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.

Journal of translational medicine - 21 Apr 2023

Alemany Silvia, Soler-Artigas María, Cabana-Domínguez Judit, Fakhreddine Dana, Llonga Natalia, Vilar-Ribó Laura, Rodríguez-Urrutia Amanda, Palacio Judit, González-Castro Ana María, Lobo Beatriz, Alonso-Cotoner Carmen, Simrén Magnus, Santos Javier, Ramos-Quiroga Josep Antoni, Ribasés Marta

Abstract excerpt

BACKGROUND: Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including depression and anxiety. Despite showing substantial heritability and being partly determined by a genetic component, the genetic underpinnings explaining the high rates of comorbidity remain largely unclear and there are no conclusive data on the temporal relationship...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Celiac Disease Research and Management

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comorbidity

Share to Gastrointestinal motility and disorders

Share to Genetic Associations and Epidemiology

Share to Genome-Wide Association Study

Share to Irritable Bowel Syndrome

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 37085903
DOI: 10.1186/s12967-023-04107-5
PMCID: PMC10120121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants.PMID 37085903Read ↗

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hitsSemantic proximity Read ↗

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.Semantic proximity Read ↗

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis.Semantic proximity Read ↗

Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic studySemantic proximity Read ↗

Genetic epidemiology of irritable bowel syndrome.Semantic proximity Read ↗

Rome III Criteria Capture Higher Irritable Bowel Syndrome SNP-Heritability and Highlight a Novel Genetic Link With Cardiovascular Traits.Semantic proximity Read ↗

Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis.Semantic proximity Read ↗

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies.Semantic proximity Read ↗

Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform TraitsSemantic proximity Read ↗

Causal relationships between psychological disorders and functional gastrointestinal disorders: a bidirectional two-sample Mendelian randomization study.Semantic proximity Read ↗

Irritable Bowel Syndrome Is Associated With Brain Health by Neuroimaging, Behavioral, Biochemical, and Genetic Analyses.Semantic proximity Read ↗

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohortsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.