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Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis.

Frontiers in immunology - 1 Jan 2024

Liu Xianqiang, Li Dingchang, Gao Wenxing, Liu Hao, Chen Peng, Zhao Yingjie, Zhao Wen, Dong Guanglong

Abstract excerpt

Background: It has been reported that COVID-19 patients have an increased risk of developing IBS; however, the underlying genetic mechanisms of these associations remain largely unknown. The aim of this study was to investigate potential shared SNPs, genes, proteins, and biological pathways between COVID-19 and IBS by assessing pairwise genetic correlations and cross-trait genetic analysis. Materials and methods:...

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COVID-19
Genetic Predisposition to Disease
Genome-Wide Association Study
Irritable Bowel Syndrome
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Open in PubMed Open full text

Identifiers

PMID: 39620219
DOI: 10.3389/fimmu.2024.1442693
PMCID: PMC11604633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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