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Rome III Criteria Capture Higher Irritable Bowel Syndrome SNP-Heritability and Highlight a Novel Genetic Link With Cardiovascular Traits.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2024

Camargo Tavares Leticia, Lopera-Maya Esteban Alexander, Bonfiglio Ferdinando, Zheng Tenghao, Sinha Trishla, Zanchetta Marques Francine, Zhernakova Alexandra, Sanna Serena, D'Amato Mauro

Abstract excerpt

BACKGROUND & AIMS: Irritable bowel syndrome (IBS) shows genetic predisposition, and large-scale genome-wide association studies (GWAS) are emerging, based on heterogeneous disease definitions. We investigated the genetic architecture of IBS defined according to gold standard Rome Criteria. METHODS: We conducted GWAS meta-analyses of Rome III IBS and its subtypes in 24,735 IBS cases and 77,149 asymptomatic control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38643935
DOI: 10.1016/j.jcmgh.2024.04.002
PMCID: PMC11176963

Genes

ADCY2
BMAL1
CLDN23
MFHAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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