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Article

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies.

Nature reviews. Gastroenterology & hepatology - 1 Nov 2022

Camilleri Michael, Zhernakova Alexandra, Bozzarelli Isotta, D'Amato Mauro

Abstract excerpt

The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably involves genetic predisposition and the effect of environmental factors. Unlike other gastrointestinal diseases with a heritable component, genetic research in IBS has been scarce and mostly characterized by small underpowered studies, leading to inconclusive results. The availability of genomic and health-related data from large...

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Biological Specimen Banks
Gastrointestinal Diseases
Genetic Predisposition to Disease
Irritable Bowel Syndrome

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35948782
DOI: 10.1038/s41575-022-00662-2

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