Article
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis.
Genome medicine - 1 Aug 2023
Tesfaye Markos, Jaholkowski Piotr, Hindley Guy F L, Shadrin Alexey A, Rahman Zillur, Bahrami Shahram, Lin Aihua, Holen Børge, Parker Nadine, Cheng Weiqiu, Rødevand Linn, Frei Oleksandr, Djurovic Srdjan, Dale Anders M, Smeland Olav B, O'Connell Kevin S, Andreassen Ole A
Abstract excerpt
BACKGROUND: Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability remains unidentified, and the genetic overlap with psychiatric and somatic disorders is not quantified beyond genome-wide genetic correlations. Here, we characterize the genetic...
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