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Article

Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs.

Nature communications - 19 Apr 2023

Han Seong Kyu, McNulty Michelle T, Benway Christopher J, Wen Pei, Greenberg Anya, Onuchic-Whitford Ana C, Jang Dongkeun, Flannick Jason, Burtt Noël P, Wilson Parker C, Humphreys Benjamin D, Wen Xiaoquan, Han Zhe, Lee Dongwon, Sampson Matthew G

Abstract excerpt

Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate specific genes and contribute to fine-mapped loci discovered via genome-wide association studies (GWAS). Efforts to maximize their accuracy are ongoing. Using 240 glomerular (GLOM) and 311 tubulointerstitial (TUBE) micro-dissected samples from human kidney biopsies, we discovered 5371 GLOM and 9787 TUBE genes with at...

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PMID: 37076491
DOI: 10.1038/s41467-023-37691-7
PMCID: PMC10115815

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