Article
Immune responses to citrullinated and homocitrullinated peptides in healthy donors are not restricted to the HLA SE shared allele and can be selected into the memory pool.
Immunology - 1 Aug 2023
Choudhury Ruhul H, Daniels Ian, Vaghela Poonam, Atabani Suha, Kirk Thomas, Symonds Peter, Cook Katherine W, Al-Omari Abdullah, Weston Daisy, Shah Sabaria, Hutchinson David, Paston Samantha J, Metheringham Rachael L, Brentville Victoria A, Durrant Lindy G
Abstract excerpt
Citrullination and homocitrullination are stress induced post-translational modifications (siPTMs) which can be recognized by T cells. Peripheral blood mononuclear cells isolated from healthy donors and rheumatoid arthritis (RA) patients were stimulated with nine siPTM-peptides. CD45RA/CD45RO depletion was employed to determine if peptide-specific responses are naïve or memory. Human leucocyte antigen (HLA)-DP4...
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