Article

Single-cell spatial transcriptome reveals pathological features of human hippocampus with sclerosis

2025-01-22

Abstract excerpt

More than half of epileptic patients ultimately turned to intractable epilepsy. Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), the most common type of intractable epilepsies, whose pathological mechanism remains elusive. Here, using 42 human hippocampal samples from surgical donors of MTLE (32 with and 10 without HS) through single-cell resolution Stereo-seq and histologcial experiments, we re...

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Literature Corpus work: 8b0bca58-8ccd-555f-9004-8d800bbf67ef
DOI: 10.1101/2025.01.21.633854

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