The protein interactome of the Neuron Specific Gene family (NSG1-3)

Abstract excerpt

<h4>ABSTRACT</h4> The Neuron-Specific Gene (NSG) family members (NSG1-3) play critical and diverse roles in neuronal protein trafficking, but their precise molecular functions remain poorly understood. Here, we employed proximity-labeling proteomics to map the interactomes of each NSG protein. Unlabeled mass spectrometry identified over 1,000 significantly enriched interactors compared with a cytoplasmic control,...

Topics

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• Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
• Calcium-Binding Proteins
• Cell Adhesion Molecules, Neuronal
• Coculture Techniques
• Extracellular Matrix Proteins
• Protein Interaction Maps
• Receptors, N-Methyl-D-Aspartate
• Synapses

Identifiers and source

Literature Corpus work

e11b1452-f555-56a6-b0d4-66da130a4284

DOI

10.64898/2025.12.07.692831