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Article

Interactome dynamics of RAF1-BRAF kinase monomers and dimers.

Scientific data - 12 Apr 2023

Iglesias-Martinez Luis F, Rauch Nora, Wynne Kieran, McCann Brendan, Kolch Walter, Rauch Jens

Abstract excerpt

RAF kinases play major roles in cancer. BRAFV600E mutants drive ~6% of human cancers. Potent kinase inhibitors exist but show variable effects in different cancer types, sometimes even inducing paradoxical RAF kinase activation. Both paradoxical activation and drug resistance are frequently due to enhanced dimerization between RAF1 and BRAF, which maintains or restores the activity of the downstream MEK-ERK...

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Identifiers

PMID: 37045861
DOI: 10.1038/s41597-023-02115-0
PMCID: PMC10097620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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