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Article

Interactome dynamics of RAF1-BRAF kinase monomers and dimers.

Scientific data - 12 Apr 2023

Iglesias-Martinez Luis F, Rauch Nora, Wynne Kieran, McCann Brendan, Kolch Walter, Rauch Jens

Abstract excerpt

RAF kinases play major roles in cancer. BRAFV600E mutants drive ~6% of human cancers. Potent kinase inhibitors exist but show variable effects in different cancer types, sometimes even inducing paradoxical RAF kinase activation. Both paradoxical activation and drug resistance are frequently due t...

Topics

Humans
Mutation
Protein Kinase Inhibitors
Proto-Oncogene Proteins B-raf
Signal Transduction
Vemurafenib
Proto-Oncogene Proteins c-raf
Proteome

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37045861
DOI: 10.1038/s41597-023-02115-0
PMCID: PMC10097620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-37045861-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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