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Article

Targeting the Raf kinases in human cancer: the Raf dimer dilemma.

British journal of cancer - 1 Jan 2018

Durrant David E, Morrison Deborah K

Abstract excerpt

The Raf protein kinases are key intermediates in cellular signal transduction, functioning as direct effectors of the Ras GTPases and as the initiating kinases in the ERK cascade. In human cancer, Raf activity is frequently dysregulated due to mutations in the Raf family member B-Raf or to alterations in upstream Raf regulators, including Ras and receptor tyrosine kinases. First-generation Raf inhibitors, such as...

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Identifiers

PMID: 29235562
DOI: 10.1038/bjc.2017.399
PMCID: PMC5765234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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