Article
The importance of Raf dimerization in cell signaling.
Small GTPases - 1 Jan 2000
Freeman Alyson K, Ritt Daniel A, Morrison Deborah K
Abstract excerpt
The Raf family of protein kinases are key signaling intermediates, acting as a central link between the membrane-bound Ras GTPases and the downstream kinases MEK and ERK. Raf kinase regulation is well-known for its complexity but only recently has it been realized that many of the mechanisms involved in Raf regulation also modulate Raf dimerization, now acknowledged to be a required step for Raf signaling in...
Topics
- Dimerization
- Extracellular Signal-Regulated MAP Kinases
- Humans
- MAP Kinase Kinase Kinases
- Mutation
- Neoplasms
- Protein Kinase Inhibitors
- Signal Transduction
- raf Kinases
- ras Proteins