Article
The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants.
Oncogene - 1 Oct 2018
Yuan Jimin, Ng Wan Hwa, Lam Paula Y P, Wang Yu, Xia Hongping, Yap Jiajun, Guan Shou Ping, Lee Ann S G, Wang Mei, Baccarini Manuela, Hu Jiancheng
Abstract excerpt
Although extensively studied for three decades, the molecular mechanisms that regulate the RAF/MEK/ERK kinase cascade remain ambiguous. Recent studies identified the dimerization of RAF as a key event in the activation of this cascade. Here, we show that in-frame deletions in the β3-αC loop activate ARAF as well as BRAF and other oncogenic kinases by enforcing homodimerization. By characterizing these RAF...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.