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Article

Pyrazinamide-resistant Tuberculosis Obscured From Common Targeted Molecular Diagnostics.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 May 2023

Modlin Samuel J, Mansjö Mikael, Werngren Jim, Ejike Chidera M, Hoffner Sven E, Valafar Faramarz

Abstract excerpt

Here, we describe a clinical case of pyrazinamide-resistant (PZA-R) tuberculosis (TB) reported as PZA-susceptible (PZA-S) by common molecular diagnostics. Phenotypic susceptibility testing (pDST) indicated PZA-R TB. Targeted Sanger sequencing reported wild-type PncA, indicating PZA-S TB. Whole Genome Sequencing (WGS) by PacBio and IonTorrent both detected deletion of a large portion of pncA, indicating PZA-R....

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Identifiers

PMID: 37043916
DOI: 10.1016/j.drup.2023.100959
PMCID: PMC10317212

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