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Article

Lung adenocarcinomas with isolated TP53 mutation: A comprehensive clinical, cytopathologic and molecular characterization.

Cancer medicine - 1 Jan 2024

Mendoza Rachelle P, Chen-Yost Heather I-Hsuan, Wanjari Pankhuri, Wang Peng, Symes Emily, Johnson Daniel N, Reeves Ward, Mueller Jeffrey, Antic Tatjana, Biernacka Anna

Abstract excerpt

BACKGROUND: TP53 mutation is present in about 50.8% of lung adenocarcinomas, frequently in combination with other genetic alterations. However, a rare subset harbors the TP53 mutation alone. METHODS: Next-generation sequencing was performed in 844 lung adenocarcinomas diagnosed by fine needle aspiration. Fourteen cases (1.7%) showed isolated TP53 alteration and were subjected to a comprehensive analysis. RESULTS:...

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Identifiers

PMID: 38164123
DOI: 10.1002/cam4.6873
PMCID: PMC10824142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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